Mechanical dispersion is associated with clinical and subclinical coronary artery disease in patients on chronic renal replacement therapy with normal left ventricular ejection fraction

Abstract Funding Acknowledgements Type of funding sources: None. Introduction Since coronary artery disease (CAD) is the leading cause mortality in patients with end-stage renal failure, early detection CAD these presenting still normal left ventricular (LV) systolic function clinical importance. Aim To investigate correlation between electrical and mechanical dispersion dialysis LV function. Material methods: This prospective study included 78 who underwent a 12-channel electrocardiogram echocardiographic examination to determine myocardial dispersion. A calcium score using cardiac computed tomography was also assessed group 20 without known CAD. Electrical defined as difference longest shortest corrected QT interval (QTc). Mechanical (MD) either standard deviation contraction duration all segments (MD_SD) or (MD_delta). The determined by strain analysis. Results Previously present 11 (14%) patients, while pathologic Q wave absent patients. No significant observed QTc both MD parameters (p > 0.05 for both). Both = 0.007 MD_SD; p 0.026 MD_delta), but not 0.584), showed discriminative power detecting previously (Figure). In CAD, neither nor MD_SD MD_delta strong total territory anterior descending (r 0.62; 0.004) Conclusion associated range (MD_delta) correlates subclinical atherosclerosis. Figure. Discriminative